abstract：:To date, three molecular markers (ER, PR, and CYP2D6) have been used in clinical setting to predict the benefit of the anti-estrogen tamoxifen therapy. Our aim was to validate new biomarker candidates predicting response to tamoxifen treatment in breast cancer by evaluating these in a meta-analysis of available transc...

journal_title：Breast cancer research and treatment

authors： Mihály Z,Kormos M,Lánczky A,Dank M,Budczies J,Szász MA,Győrffy B

更新日期：2013-07-01 00:00:00

abstract：:Neurofibromatosis type 1 (NF1) is a common dominant autosomal disorder caused by mutations in the NF1 gene. The main manifestations of NF1 are café-au-lait spots, neurofibromas, intertriginous freckling, Lisch nodules, and malignancy, including peripheral nerve sheath tumors, central nervous system gliomas, and a vari...

journal_title：Breast cancer research and treatment

authors： Campos B,Balmaña J,Gardenyes J,Valenzuela I,Abad O,Fàbregas P,Volpini V,Díez O

更新日期：2013-06-01 00:00:00

abstract：:To compare overall survival between women with unilateral breast cancer (UBC) and contralateral breast cancer (CBC). Women with UBC (N = 182,562; 95 %) and CBC (N = 8,912; 5 %) recorded in the Netherlands Cancer Registry between 1989 and 2008 were included and followed until 2010. We incorporated CBC as a time-depende...

journal_title：Breast cancer research and treatment

authors： Font-Gonzalez A,Liu L,Voogd AC,Schmidt MK,Roukema JA,Coebergh JW,de Vries E,Soerjomataram I

更新日期：2013-06-01 00:00:00

abstract：:The aromatase inhibitors exemestane and anastrozole are approved in Japan for first-line treatment of postmenopausal patients with advanced, hormone-receptor-positive breast cancer. This phase 3, randomized, double-blind study directly compared time to progression (TTP) for exemestane and anastrozole therapy in this p...

journal_title：Breast cancer research and treatment

authors： Iwata H,Masuda N,Ohno S,Rai Y,Sato Y,Ohsumi S,Hashigaki S,Nishizawa Y,Hiraoka M,Morimoto T,Sasano H,Saeki T,Noguchi S

更新日期：2013-06-01 00:00:00

abstract：:Preclinical and epidemiologic evidence supports a possible role for beta-adrenergic blocking drugs (beta-blockers), and angiotensin-converting enzyme inhibitors (ACEIs) in promoting survival after breast cancer. However, these drugs are often used concurrently with aspirin, and there is a growing body of evidence indi...

journal_title：Breast cancer research and treatment

authors： Holmes MD,Hankinson SE,Feskanich D,Chen WY

更新日期：2013-06-01 00:00:00

abstract：:The tumor-stroma ratio has previously been shown to be prognostic for patients with invasive breast cancer. We present a validation study to assess the prognostic significance in lymph node-negative, premenopausal patients from the perioperative chemotherapy trial (POP trial, 10854) conducted by the European Organizat...

journal_title：Breast cancer research and treatment

authors： Dekker TJ,van de Velde CJ,van Pelt GW,Kroep JR,Julien JP,Smit VT,Tollenaar RA,Mesker WE

更新日期：2013-06-01 00:00:00

abstract：:The clinicopathologic, mammographic, and sonographic findings in patients with pure ductal carcinoma in situ (DCIS) were assessed by estrogen receptor (ER) expression. After institutional review board approval, patients with pure DCIS evaluated from January 1996 to July 2009 with known ER status and available imaging ...

journal_title：Breast cancer research and treatment

authors： Rauch GM,Kuerer HM,Scoggins ME,Fox PS,Benveniste AP,Park YM,Lari SA,Hobbs BP,Adrada BE,Krishnamurthy S,Yang WT

更新日期：2013-06-01 00:00:00

abstract：:Treatment decisions in oncology are based on a balance between the efficacy of therapy and its side effects. Patients with metastases and patients with a limited prognosis are a particular challenge, since communication about the disease situation and the expected therapeutic benefit is difficult not only for patients...

journal_title：Breast cancer research and treatment

authors： Lux MP,Bayer CM,Loehberg CR,Fasching PA,Schrauder MG,Bani MR,Häberle L,Engel A,Heusinger K,Tänzer T,Radosavac D,Scharl A,Bauerfeind I,Gesslein J,Schulte H,Overbeck-Schulte B,Beckmann MW,Hein A

更新日期：2013-06-01 00:00:00

abstract：:FOXP3-expressing T regulatory lymphocytes (Tregs) have been described as putative mediators of immune tolerance, and thus facilitators of tumor growth. When found in association with various malignancies, Tregs are generally markers of poor clinical outcome. However, it is unknown whether they are also associated with...

journal_title：Breast cancer research and treatment

authors： Lal A,Chan L,Devries S,Chin K,Scott GK,Benz CC,Chen YY,Waldman FM,Hwang ES

更新日期：2013-06-01 00:00:00

abstract：:Heat shock protein 90 (Hsp90) facilitates maturation and stability of HER2. Combining an Hsp90 inhibitor and trastuzumab has demonstrated anti-tumor effects in patients with HER2+ breast cancer. Adults with measurable, locally advanced or metastatic HER2+ breast cancer and prior trastuzumab treatment were enrolled in ...

journal_title：Breast cancer research and treatment

authors： Modi S,Saura C,Henderson C,Lin NU,Mahtani R,Goddard J,Rodenas E,Hudis C,O'Shaughnessy J,Baselga J

更新日期：2013-05-01 00:00:00

abstract：:Knowledge about long-term consequences of breast cancer treatment on shoulder and arm function and volume in stages I-II breast cancer survivors is limited. The effects of shoulder-arm function shortly after surgery on long-term function are unknown. One hundred and ninety-four women were examined pre-surgery (T0) and...

journal_title：Breast cancer research and treatment

authors： Kootstra JJ,Dijkstra PU,Rietman H,de Vries J,Baas P,Geertzen JH,Hoekstra HJ,Hoekstra-Weebers JE

更新日期：2013-05-01 00:00:00

abstract：:Resistance to tamoxifen is a major clinical challenge in the treatment of breast cancer; however, it is still unclear which signaling pathways are the major drivers of tamoxifen-resistant growth. To characterize resistance mechanisms, we have generated different tamoxifen-resistant breast cancer cell lines from MCF-7....

journal_title：Breast cancer research and treatment

authors： Thrane S,Lykkesfeldt AE,Larsen MS,Sorensen BS,Yde CW

更新日期：2013-05-01 00:00:00

abstract：:Psoriasin (S100A7) is a calcium-binding protein that has shown to be highly expressed in high-grade ductal carcinoma in situ (DCIS) and a subset of invasive breast cancers. However, its role in invasion and metastasis is not very well known. In this study, we have shown that S100A7 differentially regulates epidermal g...

journal_title：Breast cancer research and treatment

authors： Sneh A,Deol YS,Ganju A,Shilo K,Rosol TJ,Nasser MW,Ganju RK

更新日期：2013-04-01 00:00:00

abstract：:Old age is associated with comorbidity and decreased functioning which influences treatment decisions in elderly breast cancer patients. The purpose of this study was to identify risk factors for complications after breast cancer surgery in elderly patients, and to assess mortality in patients with postoperative compl...

journal_title：Breast cancer research and treatment

authors： de Glas NA,Kiderlen M,Bastiaannet E,de Craen AJ,van de Water W,van de Velde CJ,Liefers GJ

更新日期：2013-04-01 00:00:00

abstract：:The transition from screen-film to digital mammography may have altered diagnostic evaluation of women following a positive screening examination. This study compared the use and timeliness of diagnostic imaging and biopsy for women screened with screen-film or digital mammography. Data were obtained from 35,321 posit...

journal_title：Breast cancer research and treatment

authors： Hubbard RA,Zhu W,Horblyuk R,Karliner L,Sprague BL,Henderson L,Lee D,Onega T,Buist DS,Sweet A

更新日期：2013-04-01 00:00:00

abstract：:Recently, many centers have omitted routine axillary lymph node dissection (ALND) after metastatic sentinel node biopsy in breast cancer due to a growing body of literature. However, existing guidelines of adjuvant treatment planning are strongly based on axillary nodal stage. In this study, we aim to develop a novel ...

journal_title：Breast cancer research and treatment

authors： Meretoja TJ,Audisio RA,Heikkilä PS,Bori R,Sejben I,Regitnig P,Luschin-Ebengreuth G,Zgajnar J,Perhavec A,Gazic B,Lázár G,Takács T,Kővári B,Saidan ZA,Nadeem RM,Castellano I,Sapino A,Bianchi S,Vezzosi V,Barranger E,L

更新日期：2013-04-01 00:00:00

abstract：:Detection of disseminated tumour cells (DTCs) in bone marrow by immunocytochemistry (ICC) includes morphological evaluation of cytokeratin immunopositive cells. The aim of this study was to disclose the prognostic significance of different morphological categories of ICC-positive cells according to treatment status an...

journal_title：Breast cancer research and treatment

authors： Synnestvedt M,Borgen E,Schlichting E,Schirmer CB,Renolen A,Giercksky KE,Nesland JM,Naume B

更新日期：2013-04-01 00:00:00

abstract：:Invasion factors uPA/PAI-1 are guideline-recommended (ASCO, AGO) biomarkers for decision support regarding adjuvant chemotherapy (CTX) in women with primary breast cancer. They define a high-risk group with strong benefit from adjuvant CTX and a low-risk group with uncertain benefit and excellent survival without CTX....

journal_title：Breast cancer research and treatment

authors： Jacobs VR,Kates RE,Kantelhardt E,Vetter M,Wuerstlein R,Fischer T,Schmitt M,Jaenicke F,Untch M,Thomssen C,Harbeck N

更新日期：2013-04-01 00:00:00

abstract：:Expression of the oestrogen producing enzyme, aromatase, is regulated in a tissue-specific manner by its encoding gene CYP19A1. In post-menopausal women, the major site for oestrogen production in the breast is the adipose, where CYP19A1 transcription is driven by the distal promoter I.4 (PI.4). Transcripts via this p...

journal_title：Breast cancer research and treatment

authors： To SQ,Simpson ER,Knower KC,Clyne CD

更新日期：2013-02-01 00:00:00

abstract：:In epithelial-to-mesenchymal transition (EMT) epithelial cancer cells achieve mesenchymal features, essentially helping them to metastasize. There is some evidence that EMT could be increased in triple-negative (TNBC) or basal-like breast cancers, although more precise mechanisms considering e.g. EMT-regulating transc...

journal_title：Breast cancer research and treatment

authors： Karihtala P,Auvinen P,Kauppila S,Haapasaari KM,Jukkola-Vuorinen A,Soini Y

更新日期：2013-02-01 00:00:00

abstract：:To assess the impact of patient-provider communication on adherence to tamoxifen (TAM) and aromatase inhibitors (AIs) 36 months after breast cancer (BC) diagnosis in a low-income population of women. California statewide surveys were conducted among 921 low-income women with BC at 6, 18, and 36 months after BC diagnos...

journal_title：Breast cancer research and treatment

authors： Liu Y,Malin JL,Diamant AL,Thind A,Maly RC

更新日期：2013-02-01 00:00:00

abstract：:Fibroblast growth factor receptor 2 (FGFR2) is a member of a receptor tyrosine kinase gene superfamily, involved in cell growth, invasiveness, motility, and angiogenesis, which has attracted considerable attention as a candidate gene for breast cancer (BC) since it was first identified through genome-wide association ...

journal_title：Breast cancer research and treatment

authors： Wang H,Yang Z,Zhang H

更新日期：2013-01-01 00:00:00

abstract：:Genome-Wide Association Studies have identified several loci associated with breast cancer (BC) in populations of different ethnic origins. One of the strongest associations was found in the FGFR2 gene, and MAP3K1 has been proposed as a low-penetrance BC risk factor. In this study, we evaluated the associations among ...

journal_title：Breast cancer research and treatment

authors： Jara L,Gonzalez-Hormazabal P,Cerceño K,Di Capua GA,Reyes JM,Blanco R,Bravo T,Peralta O,Gomez F,Waugh E,Margarit S,Ibañez G,Romero C,Pakomio J,Roizen G

更新日期：2013-01-01 00:00:00

abstract：:Mucinous breast cancer (MBC) is mainly a disease of postmenopausal women. Pure MBC is rare and augurs a good prognosis. In contrast, MBC mixed with other histological subtypes of invasive disease loses the more favorable prognosis. Because of the relative rarity of pure MBC, little is known about its cell and tumor bi...

journal_title：Breast cancer research and treatment

authors： Jambal P,Badtke MM,Harrell JC,Borges VF,Post MD,Sollender GE,Spillman MA,Horwitz KB,Jacobsen BM

更新日期：2013-01-01 00:00:00

abstract：:Stearoyl-CoA desaturase 1 (SCD1) is an essential regulator of fatty acid synthesis. We have previously shown that overexpression of SCD1 increases the growth of breast cancer cell lines. The purpose of this study was to determine the relationship between SCD1 expression level and clinical-pathologic characteristics an...

journal_title：Breast cancer research and treatment

authors： Holder AM,Gonzalez-Angulo AM,Chen H,Akcakanat A,Do KA,Fraser Symmans W,Pusztai L,Hortobagyi GN,Mills GB,Meric-Bernstam F

更新日期：2013-01-01 00:00:00

abstract：:Mammographic density (MD) is a strong marker of breast cancer risk, but it is debated whether the association holds, and is of a similar magnitude, for different subtypes of breast cancer defined by receptor status or gene expression profiles. A literature search conducted in June 2012 was used to identify all studies...

journal_title：Breast cancer research and treatment

authors： Antoni S,Sasco AJ,dos Santos Silva I,McCormack V

更新日期：2013-01-01 00:00:00

abstract：:Triple-negative breast cancer (TNBC) is a subtype of breast tumor with unique characteristics in terms of clinical-pathological presentation, prognosis, and response to therapy. Epidemiological investigations focusing on the identification of risk factors involved in the onset and progression of TNBCs have identified ...

journal_title：Breast cancer research and treatment

authors： Pierobon M,Frankenfeld CL

更新日期：2013-01-01 00:00:00

abstract：:Evidence suggests early events might modify adult breast cancer risk and many adolescents learn of familial and genetic risks for breast cancer. Little is known about how adolescent girls understand and respond to breast cancer risk. Semi-structured interviews with 11-19 year-old girls at high-risk and population-risk...

journal_title：Breast cancer research and treatment

authors： Bradbury AR,Patrick-Miller L,Egleston BL,Schwartz LA,Sands CB,Shorter R,Moore CW,Tuchman L,Rauch P,Malhotra S,Rowan B,Van Decker S,Schmidheiser H,Bealin L,Sicilia P,Daly MB

更新日期：2012-12-01 00:00:00

abstract：:Fulvestrant fIRst-line Study comparing endocrine Treatments is a phase II, randomized, open-label study comparing fulvestrant 500 mg with anastrozole 1 mg as first-line endocrine therapy for postmenopausal women with hormone receptor-positive (HR+) advanced breast cancer. At data cut-off, only 36 % of patients had pro...

journal_title：Breast cancer research and treatment

authors： Robertson JF,Lindemann JP,Llombart-Cussac A,Rolski J,Feltl D,Dewar J,Emerson L,Dean A,Ellis MJ

更新日期：2012-11-01 00:00:00

abstract：:Mammographic density is a strong and independent risk factor for breast cancer and is considered an intermediate marker of risk. The major predictors of premenopausal mammographic density, however, have yet to be fully elucidated. To test the hypothesis that urinary estrogen metabolism profiles are associated with mam...

journal_title：Breast cancer research and treatment

authors： Bertrand KA,Eliassen AH,Hankinson SE,Gierach GL,Xu X,Rosner B,Ziegler RG,Tamimi RM

更新日期：2012-11-01 00:00:00

abstract：:Endocrine therapy is an important therapeutic approach for the treatment of oestrogen receptor (ER)-positive breast cancer. However, a number of these endocrine therapies can fail when the tumour loses its ER expression during treatment. To date, few studies have explored the potential clinical significance of traditi...

journal_title：Breast cancer research and treatment

authors： Zhang B,Zhang X,Tang B,Zheng P,Zhang Y

更新日期：2012-11-01 00:00:00

abstract：:The association of smoking with outcomes following breast cancer prognosis is not well understood. In a cohort study called Life After Cancer Epidemiology (LACE), 2,265 women diagnosed with breast cancer were followed for a median of 12 years. We used multivariable proportional-hazards models to determine whether smok...

journal_title：Breast cancer research and treatment

authors： Braithwaite D,Izano M,Moore DH,Kwan ML,Tammemagi MC,Hiatt RA,Kerlikowske K,Kroenke CH,Sweeney C,Habel L,Castillo A,Weltzien E,Caan B

更新日期：2012-11-01 00:00:00

abstract：:Genome-wide Association Studies (GWAS) revealed novel genetic markers for breast cancer susceptibility. But little is known about the risk factors and molecular events associated with breast cancer in Arab Population. Therefore, we designed a broad study to investigate the susceptibility and prognostic implications of...

journal_title：Breast cancer research and treatment

authors： Shan J,Mahfoudh W,Dsouza SP,Hassen E,Bouaouina N,Abdelhak S,Benhadjayed A,Memmi H,Mathew RA,Aigha II,Gabbouj S,Remadi Y,Chouchane L

更新日期：2012-10-01 00:00:00

abstract：:Although younger women with breast cancer have the most to gain from receipt of optimal care, few data are available regarding their receipt of locoregional breast cancer treatments. We identified 317,596 women aged 18-64 who were diagnosed with invasive breast cancer at hospitals reporting to the National Cancer Data...

journal_title：Breast cancer research and treatment

authors： Freedman RA,Virgo KS,Labadie J,He Y,Partridge AH,Keating NL

更新日期：2012-10-01 00:00:00

abstract：:Metformin may exert anti-cancer effects through indirect (insulin-mediated) or direct (insulin-independent) mechanisms. We report results of a neoadjuvant "window of opportunity" study of metformin in women with operable breast cancer. Newly diagnosed, untreated, non-diabetic breast cancer patients received metformin ...

journal_title：Breast cancer research and treatment

authors： Niraula S,Dowling RJ,Ennis M,Chang MC,Done SJ,Hood N,Escallon J,Leong WL,McCready DR,Reedijk M,Stambolic V,Goodwin PJ

更新日期：2012-10-01 00:00:00

abstract：:Aurora kinases (AKs) regulate multiple components of mitotic cell division in eukaryotic cells. Aurora A is frequently amplified or overexpressed in breast cancer cells leading to aberrant chromosome segregation, genomic instability, and activation of oncogenic pathways. In the present studies, we determined the effec...

journal_title：Breast cancer research and treatment

authors： Fiskus W,Hembruff SL,Rao R,Sharma P,Balusu R,Venkannagari S,Smith JE,Peth K,Peiper SC,Bhalla KN

更新日期：2012-09-01 00:00:00

abstract：:HER2/neu overexpression leads to poorer prognosis and higher risk of disease reoccurrence in breast cancer patients. The causative factors responsible for increasing HER2/neu expression levels on mammary cells are not known. We investigated whether factors associated with inflammation or metastasis could induce HER2/n...

journal_title：Breast cancer research and treatment

authors： Fatunmbi M,Shelton J,Aronica SM

更新日期：2012-09-01 00:00:00

abstract：:Triple-negative breast cancer is a particularly aggressive and lethal breast cancer subtype that is more likely to be interval-detected rather than screen-detected. The purpose of this study is to discover and initially validate novel early detection biomarkers for triple-negative breast cancer using preclinical sampl...

journal_title：Breast cancer research and treatment

authors： Li CI,Mirus JE,Zhang Y,Ramirez AB,Ladd JJ,Prentice RL,McIntosh MW,Hanash SM,Lampe PD

更新日期：2012-09-01 00:00:00

abstract：:Mammographic density is a strong risk factor for breast cancer, but limited data are available in African American (AA) women. We examined the association between mammographic density and breast cancer risk in AA and white women. Cases (n = 491) and controls (n = 528) were from the Carolina Breast Cancer Study (CBCS) ...

journal_title：Breast cancer research and treatment

authors： Razzaghi H,Troester MA,Gierach GL,Olshan AF,Yankaskas BC,Millikan RC

更新日期：2012-09-01 00:00:00

abstract：:Clinical evidence regarding the value of MRI for therapy responses assessment in breast cancer is increasing. The objective of this study is to compare the diagnostic capability of diffusion-weighted MR imaging (DW-MRI) and contrast-enhanced MR imaging (CE-MRI) to evaluate and predict pathological response in breast c...

journal_title：Breast cancer research and treatment

authors： Wu LM,Hu JN,Gu HY,Hua J,Chen J,Xu JR

更新日期：2012-08-01 00:00:00